October 27, 2020
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Figuring out which dermal filler is right for you is not an easy job. That is especially true if you must choose between Radiesse and Juvederm. Both brands are notorious for their excellent quality and for the long-lasting skin rejuvenating results they deliver. The dilemma gets even harder because they have similar anti-aging and anti-wrinkle effects. What makes one different from the other is that they achieve these effects in their own way.


Juvederm and Radiesse are FDA-approved skin fillers. They each have a great filling effect and that is why they can be used for the correction of wrinkles and skin depressions such as marionette lines and nasolabial folds. In addition to that, these top-performing filler injections have volumizing properties. That allows them to treat volume loss under the skin and to deliver patients with simple and minimally-invasive augmentation of chin and cheeks.

  • Temporary removal of fine to severe lines, wrinkles, and folds
  • Non-surgical augmentation of the chin
  • Adding volume to the cheek area
  • Skin rejuvenation

But it may come as a surprise to you that they are two different types of injectable fillers. Juvederm is based on non-animal Hyaluronic Acid or HA, while Radiesse has Calcium Hydroxylapatite (CaHA) as a main active ingredient. HA is found naturally in the human body and it is 100% biocompatible even when it is synthetically made through a bio-fermentation process as it is the case with the HA in Juvederm. This substance also has fantastic moisturizing properties. CaHA, on the other hand, is made by natural components that are present in our organism. This means that it too is highly tolerated by humans. However, its key active ingredient is viewed by the human organism as a foreign body which triggers a reaction in the skin, making it produce extra collagen. In that way, this structural protein can gradually rejuvenate and improve the appearance of dull, tired, and/or aging skin.

Video: How does the Radiesse wrinkle filler work?


Despite the different composition of the two dermal filler brands, a treatment involving their use is almost the same. Both Juvederm and Radiesse are applied via a series of injections in the target area. The procedure is swift and a board-certified plastic surgeon can complete it in less than an hour. It does not involve pain and patients can quickly get back to their daily tasks. Typically, the desired results are achieved with one session.

When it comes to side effects, swelling, redness, and bruising around the injection points are the most commonly observed ones. They subside not long after the procedure. Allergies and other unwanted reactions are also possible but are rare. Nevertheless, Hyaluronic Acid fillers like Juvederm are generally better tolerated compared to CaHA ones such as Radiesse.

Results and duration

The anti-wrinkle and volumizing effects of these products are instant. Wrinkles are immediately filled and the lost volume is instantly restored. The collagen-boosting properties of Radiesse, however, take time to work. For that reason, patients will enjoy the full results of the filler treatment in a week.

When it comes to the longevity of the effects of these dermal fillers, Radiesse is the longer-lasting of the two. It can take the body up to two years to completely dissolve Calcium Hydroxylapatite. With Juvederm, the duration of the achieved results varies from product to product because the brand’s range consists of filler injections of different concentration and particle size. Juvederm Vollure XC (formerly Volift) has one of the highest cross-linking rates and HA concentrations in the line. Thanks to that, it can reshape the nose and correct medium to severe wrinkles and folds for a maximum of 18 months. In contrast, Juvederm Ultra 3 and Ultra 4 normally wear off in 6-12 months.

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